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Multiple Choice

Which route is preferred for glucagon administration when IV access is not available?

When IV access isn’t available, the goal is to raise blood glucose quickly using a route that provides reliable absorption. Intramuscular glucagon fits that need because it is absorbed rapidly from muscle and reliably stimulates the liver to release glucose, helping to restore consciousness and counteract hypoglycemia promptly. Subcutaneous administration tends to be slower and more variable in onset, which isn’t ideal in an emergency. Nasal glucagon can be convenient, but intramuscular glucagon remains the standard in many EMS settings due to its dependable performance and ease of use for responders.

When IV access isn’t available, the goal is to raise blood glucose quickly using a route that provides reliable absorption. Intramuscular glucagon fits that need because it is absorbed rapidly from muscle and reliably stimulates the liver to release glucose, helping to restore consciousness and counteract hypoglycemia promptly. Subcutaneous administration tends to be slower and more variable in onset, which isn’t ideal in an emergency. Nasal glucagon can be convenient, but intramuscular glucagon remains the standard in many EMS settings due to its dependable performance and ease of use for responders.