A 7-year-old female has been prescribed antibiotics for an ear infection with a rash on her neck and face. Which medication should be administered?

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Recognizing a potential medication reaction is the main idea here. The rash on the neck and face that appears after starting an antibiotic suggests a drug allergy rather than a simple infection symptom. An antihistamine, such as diphenhydramine, is used to counteract the effects of histamine released during allergic reactions. By blocking histamine receptors, it reduces itching, redness, and hives, helping the rash feel better and preventing further irritation.

The other options don’t address the allergic mechanism. An antibiotic would not relieve the rash caused by an allergy and could worsen the reaction. Pain relievers like acetaminophen or ibuprofen help with fever or discomfort but don’t treat the allergic symptoms themselves. If the reaction progresses—especially with trouble breathing, swelling of the face or tongue, or widespread hives—urgent medical care is needed.